Glucocorticoid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Glucocorticoid biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WEE1, CACNA1G, and KDM1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WEE1 grouped by Glucocorticoid biosynthetic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	WEE1 →	+0.222	+0.180	.002	<.001	3	4
BLOOD_Myeloma	CACNA1G →	+0.178	+0.260	<.001	.003	3	3
BLOOD_Leukemia	KDM1A →	+0.445	+1.666	.004	.004	3	3
LIVER	APOH →	-0.191	-2.001	.004	.004	2	4
BONE	DHX35 →	+0.404	+1.433	.001	.004	3	3
BONE	CD151 →	-0.324	-1.447	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WEE1 by Glucocorticoid biosynthetic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →