Androgen biosynthetic process

Across TCGA cell cohorts, RNA activity of the Androgen biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF76, WDR76, and PDHB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF76 grouped by Androgen biosynthetic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF76 →	-0.252	-0.267	<.001	.003	3	5
SKIN	WDR76 →	+0.191	+0.780	.005	.003	3	3
LIVER	PDHB →	+0.329	+1.949	.004	<.001	3	3
LARGE_INTESTINE	IGBP1 →	-0.254	-0.268	<.001	.006	3	3
OVARY	HAO1 →	+0.594	+1.481	.001	.003	3	3
SKIN	CPA2 →	-0.159	-1.261	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF76 by Androgen biosynthetic process activity — BLOOD_Leukemia

Explore this box plot interactively →