Progesterone biosynthetic process

Across TCGA patient cohorts, RNA activity of the Progesterone biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STARD3, CAVIN2_S203, and SYNPO2_S604, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Progesterone biosynthetic process activity versus STARD3 in BRCA (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STARD3 →	+0.672	+0.955	<.001	<.001	3	3
COAD	CAVIN2_S203 →	-0.900	-0.656	.009	<.001	3	3
PDAC	SYNPO2_S604 →	+0.681	+0.248	<.001	<.001	3	3
GBM	SBF1_S1078 →	+0.261	+0.617	.003	.005	3	2
LSCC	SCRIB_S1300 →	-0.932	-1.620	<.001	<.001	3	2
GBM	SRA1_S69 →	-0.518	-0.907	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006701 vs STARD3 — BRCA

Explore this scatter interactively →