Bile acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Bile acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGDH, BCO2, and GPN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Bile acid biosynthetic process activity versus UGDH in LUNG_NSCLC_LUSC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	UGDH →	+3.556	+0.248	<.001	.004	3	6
LIVER	BCO2 →	+1.035	+0.345	<.001	<.001	3	5
LIVER	GPN1 →	-0.699	-0.405	.003	.002	3	5
LARGE_INTESTINE	HMGA1 →	-1.398	-0.202	<.001	.009	3	5
LUNG_SCLC	PPIC →	+3.403	+0.245	<.001	<.001	3	5
LUNG_SCLC	NAPRT →	+1.236	+0.206	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006699 vs UGDH — LUNG_NSCLC_LUSC

Explore this scatter interactively →