Steroid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Steroid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CES1, MYO1D, and MYLK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid biosynthetic process activity versus CES1 in LSCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CES1 →	+0.928	+0.020	<.001	<.001	3	7
BRCA	MYO1D →	+0.411	+0.022	<.001	<.001	3	7
GBM	MYLK →	+0.623	+0.028	<.001	.001	3	7
LUAD	FCSK →	+0.251	+0.021	.008	.004	3	6
GBM	SMCHD1 →	-0.277	-0.029	<.001	<.001	3	6
GBM	TDP1 →	-0.380	-0.041	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006694 vs CES1 — LSCC

Explore this scatter interactively →