Steroid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Steroid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP128, SEH1L, and SH2D4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid biosynthetic process activity versus CEP128 in PDAC (Pearson r = -0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CEP128 →	-0.278	-0.140	.006	.003	3	4
PDAC	SEH1L →	-0.326	-0.107	<.001	<.001	3	4
BRCA	SH2D4A →	+0.897	+0.172	<.001	<.001	3	4
BRCA	TGIF2 →	-0.535	-0.156	.001	.002	3	4
BRCA	TNF →	-0.736	-0.138	.002	.008	3	4
GBM	RPL5P24 →	-1.037	-0.176	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006694 vs CEP128 — PDAC

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