Steroid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Steroid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC27A3, SEC14L2, and MAP6D1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC27A3 grouped by Steroid biosynthetic process-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC27A3 →	+1.913	+0.978	.001	<.001	3	5
SOFT_TISSUE	SEC14L2 →	-1.239	-1.315	<.001	<.001	3	4
SKIN	MAP6D1 →	+0.935	+1.077	<.001	<.001	3	4
SKIN	MARS2 →	+0.662	+1.024	<.001	<.001	3	4
SKIN	FLT3LG →	-1.126	-1.011	<.001	<.001	3	4
LIVER	ARHGAP23 →	-4.057	-1.704	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC27A3 by Steroid biosynthetic process activity — SKIN

Explore this box plot interactively →