Steroid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Steroid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HMGCS1, FDFT1, and DHCR7, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid biosynthetic process activity versus HMGCS1 in LUNG_NSCLC_LUAD (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HMGCS1 →	+2.034	+0.159	<.001	<.001	3	20
BONE	FDFT1 →	+1.626	+0.110	<.001	<.001	3	18
PANCREAS	DHCR7 →	+1.634	+0.111	<.001	.002	3	17
BONE	MSMO1 →	+1.806	+0.173	<.001	<.001	3	17
LUNG_NSCLC_LUAD	SCD →	+1.871	+0.107	<.001	<.001	3	17
URINARY_TRACT	MVK →	+1.403	+0.143	.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006694 vs HMGCS1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →