Steroid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Steroid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGD, MVD, and IDI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Steroid biosynthetic process activity versus PGD in STOMACH (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PGD →	+1.050	+0.272	.003	.005	3	6
STOMACH	MVD →	+1.913	+0.488	.001	<.001	3	6
STOMACH	IDI1 →	+1.093	+0.369	.007	.001	3	6
BREAST	FDPS →	+0.860	+0.275	.002	.004	2	7
STOMACH	WDR54 →	-1.492	-0.259	.006	.008	3	5
SKIN	HMGCS1 →	+1.447	+0.383	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006694 vs PGD — STOMACH

Explore this scatter interactively →