Leukotriene metabolic process

Across TCGA cell cohorts, RNA activity of the Leukotriene metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOC2, ARID2, and CTSD, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EXOC2 grouped by Leukotriene metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EXOC2 →	+0.675	+1.256	<.001	.001	3	4
OESOPHAGUS	ARID2 →	+0.850	+1.438	.003	.002	3	4
LUNG_NSCLC_LUSC	CTSD →	-2.095	-1.486	.008	.001	3	4
SKIN	LIMS3 →	-0.754	-0.647	.002	.009	3	4
STOMACH	MAVS →	-0.643	-0.922	.009	.001	3	4
UPPER_AERODIGESTIVE_TRACT	UBAP1 →	-1.400	-1.520	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EXOC2 by Leukotriene metabolic process activity — LIVER

Explore this box plot interactively →