Glycosphingolipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Glycosphingolipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ONECUT1, EML6, and MTIF3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycosphingolipid biosynthetic process activity versus ONECUT1 in PDAC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ONECUT1 →	-1.410	-0.174	<.001	<.001	3	3
LSCC	EML6 →	-0.357	-0.371	.006	.002	2	4
BRCA	MTIF3 →	+0.346	+0.382	.002	.005	3	2
BRCA	SAP18 →	+0.242	+0.291	.003	.005	3	2
BRCA	SRP68P1 →	+0.484	+0.290	.005	.005	3	2
LUAD	MORN3 →	+0.607	+0.657	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006688 vs ONECUT1 — PDAC

Explore this scatter interactively →