Glucosylceramide metabolic process

Across TCGA patient cohorts, RNA activity of the Glucosylceramide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, TOP2A_S1247, and ARPC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucosylceramide metabolic process activity versus TLN1 in GBM (Pearson r = -0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TLN1 →	+0.375	+0.082	<.001	<.001	3	6
LSCC	TOP2A_S1247 →	-0.834	-0.058	<.001	.003	3	6
GBM	ARPC2 →	+0.240	+0.085	<.001	<.001	3	6
LSCC	SELL →	+0.605	+0.095	<.001	<.001	3	6
CCRCC	FGD5 →	+0.290	+0.067	<.001	<.001	3	6
BRCA	TOP2A_S1377 →	-0.905	-0.063	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006678 vs TLN1 — GBM

Explore this scatter interactively →