Glucosylceramide metabolic process

Across TCGA cell cohorts, RNA activity of the Glucosylceramide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMD1, PRKCZ, and COPS9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMD1 grouped by Glucosylceramide metabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PSMD1 →	-0.688	-1.038	.002	.004	3	5
BLOOD_Lymphoma	PRKCZ →	+3.150	+2.277	.008	<.001	3	5
LUNG_SCLC	COPS9 →	-0.836	-1.232	.007	.003	2	5
BLOOD_Lymphoma	KISS1R →	+4.055	+2.096	.003	.006	3	4
BLOOD_Lymphoma	ADAM8 →	+5.020	+2.277	.009	<.001	3	4
LARGE_INTESTINE	PRPF38B →	+0.916	+1.643	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMD1 by Glucosylceramide metabolic process activity — LUNG_SCLC

Explore this box plot interactively →