Ceramide metabolic process

Across TCGA patient cohorts, RNA activity of the Ceramide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNMT, TOP2A, and MRTO4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ceramide metabolic process activity versus RNMT in GBM (Pearson r = -0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RNMT →	-0.216	-0.033	<.001	<.001	3	6
GBM	TOP2A →	-0.534	-0.033	<.001	<.001	3	6
GBM	MRTO4 →	-0.380	-0.044	<.001	<.001	3	6
BRCA	RCL1 →	-0.320	-0.020	<.001	<.001	3	6
CCRCC	GEMIN5 →	-0.189	-0.019	.002	.004	3	5
GBM	RFC3 →	-0.258	-0.036	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006672 vs RNMT — GBM

Explore this scatter interactively →