Sphingolipid metabolic process

Across TCGA patient cohorts, RNA activity of the Sphingolipid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, WDR43_S77, and RPS5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid metabolic process activity versus SMC2 in LSCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SMC2 →	-0.545	-0.039	<.001	<.001	3	7
OV	WDR43_S77 →	-1.035	-0.025	<.001	<.001	3	7
GBM	RPS5 →	-0.180	-0.036	.002	.001	3	7
GBM	RFC1_S368 →	-0.626	-0.041	<.001	<.001	3	7
PDAC	EPN1 →	+0.163	+0.024	.001	.001	3	7
GBM	PRPF8 →	-0.247	-0.040	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006665 vs SMC2 — LSCC

Explore this scatter interactively →