Sphingolipid metabolic process

Across TCGA patient cohorts, RNA activity of the Sphingolipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUM3, TMEM247, and GUCY1A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Sphingolipid metabolic process activity versus PUM3 in PDAC (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PUM3 →	-0.246	-0.165	.004	.003	3	4
GBM	TMEM247 →	+0.303	+0.160	.001	.002	3	3
UCEC	GUCY1A1 →	-0.694	-0.140	.001	.009	3	3
LSCC	TMX3 →	-0.502	-0.133	.001	.006	3	3
LSCC	SNRPFP1 →	+0.324	+0.157	.004	.003	3	3
BRCA	GPRC5A →	+1.492	+0.290	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006665 vs PUM3 — PDAC

Explore this scatter interactively →