Phosphatidylserine metabolic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylserine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIM2, FBXW7, and ART4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylserine metabolic process activity versus TRIM2 in PDAC (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TRIM2 →	-0.511	-0.751	.001	.005	3	4
PDAC	FBXW7 →	-0.238	-0.827	.005	.004	3	4
PDAC	ART4 →	-0.773	-0.871	.001	.002	3	4
PDAC	FAM120B →	-0.188	-0.728	.001	<.001	3	4
GBM	ASH1L →	-0.373	-0.186	<.001	<.001	3	4
CCRCC	TMEM131L →	-0.421	-0.867	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006658 vs TRIM2 — PDAC

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