Phosphatidylserine metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylserine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OXCT1, SCML2, and APOM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OXCT1 grouped by Phosphatidylserine metabolic process-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OXCT1 →	-1.990	-1.120	<.001	.002	3	4
KIDNEY	SCML2 →	-1.295	-1.189	<.001	<.001	3	4
KIDNEY	APOM →	+0.568	+1.067	.004	.001	2	5
UPPER_AERODIGESTIVE_TRACT	TNXB →	+0.740	+1.590	.003	<.001	3	4
LUNG_SCLC	CASS4 →	+0.106	+0.849	.006	.002	3	4
PANCREAS	DOCK7 →	-0.797	-0.907	<.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OXCT1 by Phosphatidylserine metabolic process activity — KIDNEY

Explore this box plot interactively →