Phosphatidylserine metabolic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylserine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD12, FAM110A, and CHKA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylserine metabolic process activity versus ABHD12 in CNS (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ABHD12 →	+0.916	+0.910	<.001	<.001	3	6
BLOOD_Myeloma	FAM110A →	+0.881	+0.391	<.001	.002	3	5
STOMACH	CHKA →	+1.020	+1.468	<.001	.002	2	6
LUNG_SCLC	CALCOCO1 →	+1.084	+0.486	<.001	<.001	3	4
OVARY	DECR1 →	-1.214	-1.018	.005	.009	2	5
BLOOD_Lymphoma	RNF112 →	-0.472	-0.551	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006658 vs ABHD12 — CNS

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