Phosphatidylglycerol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylglycerol biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAVS, ARFGAP2, and RPL14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol biosynthetic process activity versus MAVS in COAD (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MAVS →	+0.283	+0.030	<.001	<.001	3	5
BRCA	ARFGAP2 →	+0.211	+0.021	<.001	.005	3	5
BRCA	RPL14 →	-0.262	-0.025	.006	.001	3	4
LUAD	FASN_T2204 →	-0.507	-0.026	.001	.009	3	4
COAD	FAT1 →	-0.254	-0.031	.005	<.001	3	4
BRCA	GZF1_S613 →	+0.612	+0.039	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006655 vs MAVS — COAD

Explore this scatter interactively →