Phosphatidylglycerol biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylglycerol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNORD104, SNHG20, and ARHGAP27P1-BPTFP1-KPNA2P3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol biosynthetic process activity versus SNORD104 in BRCA (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SNORD104 →	+0.952	+0.598	.002	.003	3	4
BRCA	SNHG20 →	+0.476	+0.435	<.001	<.001	3	4
UCEC	ARHGAP27P1-BPTFP1-KPNA2P3 →	+0.319	+0.120	.009	.007	3	4
BRCA	TMEM91 →	+0.466	+0.501	.008	.003	3	3
BRCA	SAP30BP →	+0.309	+0.368	.001	.002	3	3
BRCA	PAXIP1-DT →	+0.449	+0.429	.006	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006655 vs SNORD104 — BRCA

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