Glycerophospholipid metabolic process

Across TCGA patient cohorts, RNA activity of the Glycerophospholipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1LC3A, ECHDC3, and CES4A, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glycerophospholipid metabolic process activity versus MAP1LC3A in COAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MAP1LC3A →	-1.083	-0.233	.001	.008	3	1
COAD	ECHDC3 →	-2.075	-0.321	<.001	<.001	3	1
COAD	CES4A →	-0.832	-0.246	.002	.002	3	1
COAD	TRPC6P →	-0.123	-0.535	.008	.006	3	1
COAD	LINC00276 →	-0.020	-0.533	.005	.006	3	1
COAD	OR5BT1P →	-0.089	-0.552	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006650 vs MAP1LC3A — COAD

Explore this scatter interactively →