Phosphatidylethanolamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phosphatidylethanolamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPN1, ETS2, and C1QTNF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylethanolamine biosynthetic process activity versus RPN1 in LUNG_NSCLC_LUAD (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RPN1 →	+0.834	+1.330	.001	.002	3	4
LUNG_NSCLC_LUAD	ETS2 →	+1.658	+1.307	.005	<.001	3	3
LUNG_NSCLC_LUAD	C1QTNF1 →	+2.655	+1.238	.001	.002	3	3
OESOPHAGUS	CAMK2N1 →	+2.852	+1.633	.001	<.001	3	3
OESOPHAGUS	PYM1 →	+1.679	+1.644	.003	<.001	3	3
OESOPHAGUS	SLC16A10 →	-1.058	-1.345	.008	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006646 vs RPN1 — LUNG_NSCLC_LUAD

Explore this scatter interactively →