Monoacylglycerol biosynthetic process

Across TCGA cell cohorts, RNA activity of the Monoacylglycerol biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRODH, CHN2, and TMEM245, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRODH grouped by Monoacylglycerol biosynthetic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRODH →	-2.510	-0.974	.002	.001	3	3
BREAST	CHN2 →	-1.214	-1.016	.005	.003	3	3
BREAST	TMEM245 →	+0.718	+0.834	.009	.006	3	3
BREAST	HPCAL1 →	+1.114	+0.947	.001	.002	3	3
BREAST	ABCC11 →	-2.411	-0.933	<.001	<.001	3	3
BREAST	AFAP1L1 →	+1.463	+1.056	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRODH by Monoacylglycerol biosynthetic process activity — BREAST

Explore this box plot interactively →