Fatty acid beta-oxidation

Across TCGA patient cohorts, RNA activity of the Fatty acid beta-oxidation pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAOA, AK1, and FIS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation activity versus MAOA in PDAC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MAOA →	+0.493	+0.037	.001	<.001	3	6
BRCA	AK1 →	+0.404	+0.037	.001	<.001	3	6
HNSC	FIS1 →	+0.252	+0.047	.002	.001	3	6
CCRCC	PGPEP1 →	+0.431	+0.050	<.001	<.001	3	6
HNSC	MEFV_S179 →	-0.536	-0.035	<.001	.006	3	6
BRCA	NFIA →	+0.526	+0.030	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006635 vs MAOA — PDAC

Explore this scatter interactively →