Fatty acid beta-oxidation

Across TCGA pan-cancer cohorts, RNA activity of the Fatty acid beta-oxidation pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 76 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Fatty acid beta-oxidation pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and BRCA, show the opposite pattern, with higher activity associated with better survival.

LGG, KIRP, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Tertile	All	0.382	0.603	<.001	39	view →
KIRP	DFS	Tertile	II,III,IV	1.000	0.301	.005	37	view →
BRCA	OS	Quartile	III,IV	0.919	0.747	.003	32	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	24	view →
CHOL	OS	Median	II,III,IV	0.288	0.830	.007	23	view →
SCLC	OS	Median	All	0.792	0.626	.013	20	view →
LIHC	DFS	Median	All	0.529	0.388	.010	18	view →
READ	DFS	Median	III,IV	0.893	0.595	.020	17	view →
UVM	OS	Tertile	All	0.391	0.792	.013	16	view →
GBM	OS	Tertile	All	0.197	0.526	<.001	15	view →
LUSC	DFS	Median	II,III,IV	0.670	0.755	.009	15	view →
MESO	DFS	Quartile	II,III,IV	0.363	0.135	.025	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0006635–LGG (OS)

Open the LGG breakdown →