Fatty acid beta-oxidation

Across TCGA cell cohorts, RNA activity of the Fatty acid beta-oxidation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC44A3, ABCC3, and FXYD3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid beta-oxidation activity versus SLC44A3 in LARGE_INTESTINE (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC44A3 →	+2.603	+0.261	<.001	<.001	3	8
LARGE_INTESTINE	ABCC3 →	+2.283	+0.216	.001	.001	3	7
LARGE_INTESTINE	FXYD3 →	+2.899	+0.171	.003	.007	3	6
PANCREAS	MMEL1 →	+2.565	+0.337	<.001	.001	3	6
LIVER	FRK →	+1.488	+0.110	.001	.005	3	6
PANCREAS	POLR1E →	-1.286	-0.354	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006635 vs SLC44A3 — LARGE_INTESTINE

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