Fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UFL1, DDX47, and POLA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UFL1 grouped by Fatty acid biosynthetic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	UFL1 →	+0.922	+0.219	<.001	<.001	3	4
OESOPHAGUS	DDX47 →	+0.657	+0.216	.005	.001	3	4
SOFT_TISSUE	POLA1 →	+1.082	+1.070	<.001	.008	3	3
SOFT_TISSUE	SRFBP1 →	+0.404	+0.846	.007	.006	3	3
SOFT_TISSUE	PSMD12 →	+1.088	+1.334	<.001	.001	3	3
OESOPHAGUS	ADGRF1 →	+4.325	+0.316	.005	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UFL1 by Fatty acid biosynthetic process activity — OESOPHAGUS

Explore this box plot interactively →