Fatty acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Fatty acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP17A, LAMC2, and AJM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty acid biosynthetic process activity versus AKAP17A in SKIN (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	AKAP17A →	+0.691	+0.120	.002	.003	3	5
URINARY_TRACT	LAMC2 →	-4.142	-0.442	.001	.003	3	4
SKIN	AJM1 →	+0.552	+0.122	.003	.002	3	4
BLOOD_Myeloma	HPS1 →	+0.868	+0.337	<.001	.003	3	4
OVARY	SLC30A5 →	+0.680	+0.226	<.001	<.001	3	4
URINARY_TRACT	MSH5 →	+1.350	+0.334	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006633 vs AKAP17A — SKIN

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