"SRP-dependent cotranslational protein targeting to membrane, translocation"

Across TCGA patient cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, translocation" pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PAPSS2, ZNF185_S153, and NMT2_S38, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "SRP-dependent cotranslational protein targeting to membrane, translocation" activity versus PAPSS2 in CCRCC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PAPSS2 →	+0.482	+0.041	<.001	.002	3	4
HNSC	ZNF185_S153 →	-1.106	-0.086	<.001	.002	3	4
LSCC	NMT2_S38 →	+0.405	+0.039	.001	.006	3	4
LSCC	USP48 →	+0.326	+0.052	.001	.003	3	3
COAD	AHNAK2_S2666 →	-0.577	-0.036	<.001	.003	3	3
HNSC	FOXP4_S554 →	+0.638	+0.072	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006616 vs PAPSS2 — CCRCC

Explore this scatter interactively →