"SRP-dependent cotranslational protein targeting to membrane, translocation"

Across TCGA cell cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, translocation" pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP31, DYRK2, and CCDC61, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP31 grouped by "SRP-dependent cotranslational protein targeting to membrane, translocation"-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	USP31 →	-0.907	-0.203	<.001	.005	3	4
BLOOD_Myeloma	DYRK2 →	-1.110	-0.173	.004	.009	3	3
LUNG_SCLC	CCDC61 →	-0.924	-0.197	.003	<.001	3	3
LUNG_SCLC	HDC →	+0.133	+0.200	.004	.007	3	3
LUNG_NSCLC_LUAD	SH3PXD2B →	-1.698	-0.206	.001	.005	3	3
BREAST	ABHD17B →	-1.079	-0.224	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP31 by "SRP-dependent cotranslational protein targeting to membrane, translocation" activity — OESOPHAGUS

Explore this box plot interactively →