"SRP-dependent cotranslational protein targeting to membrane, translocation"

Across TCGA cell cohorts, RNA activity of the "SRP-dependent cotranslational protein targeting to membrane, translocation" pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HARS1, VEGFA, and KRI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "SRP-dependent cotranslational protein targeting to membrane, translocation" activity versus HARS1 in SKIN (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HARS1 →	+0.477	+0.179	.003	.003	3	5
SOFT_TISSUE	VEGFA →	+2.372	+0.196	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	KRI1 →	+1.101	+0.267	.001	.001	3	5
SOFT_TISSUE	APH1A →	-0.546	-0.192	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	GCDH →	+1.035	+0.296	.002	.008	3	5
UPPER_AERODIGESTIVE_TRACT	PURA →	+0.825	+0.255	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006616 vs HARS1 — SKIN

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