Cotranslational protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Cotranslational protein targeting to membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNPO_S838, ZEB2, and RTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cotranslational protein targeting to membrane activity versus SYNPO_S838 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SYNPO_S838 →	+0.642	+0.035	.003	.004	3	5
LSCC	ZEB2 →	+0.319	+0.042	.001	.004	3	5
OV	RTN1 →	+0.715	+0.048	<.001	<.001	3	5
LSCC	CTNNB1 →	-0.277	-0.038	.001	.001	3	5
LSCC	EPN3_S449 →	-0.730	-0.041	.006	<.001	3	5
CCRCC	BASP1 →	+0.487	+0.025	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006613 vs SYNPO_S838 — BRCA

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