Cotranslational protein targeting to membrane

Across TCGA pan-cancer cohorts, RNA activity of the Cotranslational protein targeting to membrane pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 27 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Cotranslational protein targeting to membrane pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

ACC, KICH, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.439	0.767	<.001	128	view →
KICH	DFS	Quartile	II,III,IV	0.200	0.874	<.001	73	view →
KIRC	DFS	Tertile	All	0.523	0.719	<.001	54	view →
STAD	DFS	Quartile	II,III,IV	0.565	0.732	.012	36	view →
HNSC	DFS	Quartile	III,IV	0.681	0.487	.010	30	view →
KIRP	OS	Tertile	All	0.572	0.852	<.001	25	view →
LGG	DFS	Tertile	All	0.752	0.872	<.001	23	view →
SKCM	OS	Median	IV	0.867	0.225	.001	23	view →
BLCA	DFS	Median	III,IV	0.187	0.408	<.001	21	view →
UCS	DFS	Median	III,IV	0.541	0.158	.003	20	view →
LIHC	OS	Median	II,III,IV	0.918	0.626	.001	20	view →
LUSC	DFS	Tertile	II,III,IV	0.263	0.477	.006	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0006613–ACC (OS)

Open the ACC breakdown →