Cotranslational protein targeting to membrane

Across TCGA patient cohorts, RNA activity of the Cotranslational protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP68, SCHIP1, and PKNOX1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cotranslational protein targeting to membrane activity versus CEP68 in GBM (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEP68 →	-0.359	-0.115	.001	.002	3	6
CCRCC	SCHIP1 →	-0.466	-0.174	<.001	<.001	3	6
PDAC	PKNOX1 →	-0.250	-0.200	.005	.001	3	5
PDAC	ZBED5 →	-0.441	-0.238	<.001	<.001	3	5
LSCC	URGCP →	-0.388	-0.133	.001	<.001	3	5
PDAC	STRN →	-0.303	-0.213	<.001	.003	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006613 vs CEP68 — GBM

Explore this scatter interactively →