Cotranslational protein targeting to membrane

Across TCGA cell cohorts, RNA activity of the Cotranslational protein targeting to membrane pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBBP5, MAML1, and MISP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBBP5 grouped by Cotranslational protein targeting to membrane-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RBBP5 →	-0.483	-0.375	.002	.004	3	4
OVARY	MAML1 →	-0.620	-0.184	.001	.009	3	4
PANCREAS	MISP →	+2.520	+0.318	.001	<.001	2	5
BREAST	FAM53C →	-0.548	-0.296	.002	<.001	3	4
BREAST	CDC25C →	-0.623	-0.229	<.001	<.001	3	4
BREAST	TUB →	-1.163	-0.247	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBBP5 by Cotranslational protein targeting to membrane activity — STOMACH

Explore this box plot interactively →