Protein export from nucleus

Across TCGA cell cohorts, RNA activity of the Protein export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf131, DIP2A, and CCDC40, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf131 grouped by Protein export from nucleus-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf131 →	-0.511	-0.118	.004	.005	3	4
BONE	DIP2A →	+0.777	+0.142	.003	.001	3	3
BREAST	CCDC40 →	+1.010	+0.126	.001	.009	2	4
BLOOD_Leukemia	CIAPIN1 →	-0.560	-0.248	.002	.003	3	3
BLOOD_Leukemia	PLPP1 →	+1.694	+0.225	.001	.002	3	3
LUNG_NSCLC_LUSC	HMGCL →	-0.666	-0.085	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf131 by Protein export from nucleus activity — LARGE_INTESTINE

Explore this box plot interactively →