NLS-bearing protein import into nucleus

Across TCGA cell cohorts, RNA activity of the NLS-bearing protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRADA, PARP4, and MCRIP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STRADA grouped by NLS-bearing protein import into nucleus-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	STRADA →	-0.736	-0.190	.001	.006	3	5
BLOOD_Leukemia	PARP4 →	+0.867	+1.047	.001	.005	3	3
PANCREAS	MCRIP2 →	+0.743	+0.240	<.001	<.001	3	3
LUNG_NSCLC_LUAD	DDX42 →	-0.451	-0.139	.001	<.001	2	4
LUNG_NSCLC_LUAD	MT-CO3 →	+0.877	+0.139	<.001	<.001	3	3
STOMACH	CCNT2 →	-0.788	-0.223	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STRADA by NLS-bearing protein import into nucleus activity — STOMACH

Explore this box plot interactively →