NLS-bearing protein import into nucleus

Across TCGA cell cohorts, RNA activity of the NLS-bearing protein import into nucleus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KPNA3, SKP2, and DBF4B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, NLS-bearing protein import into nucleus activity versus KPNA3 in KIDNEY (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	KPNA3 →	+1.682	+0.395	.004	.001	3	8
PANCREAS	SKP2 →	+1.113	+0.289	.003	<.001	3	8
PANCREAS	DBF4B →	+0.855	+0.207	<.001	.005	3	8
OVARY	SF3A3 →	+0.723	+0.328	.007	.001	3	8
URINARY_TRACT	TTL →	+1.499	+0.492	.004	<.001	3	7
SKIN	NUP188 →	+1.024	+0.193	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006607 vs KPNA3 — KIDNEY

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