Polyamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Polyamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMOX, AMD1, and LINC01433, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine biosynthetic process activity versus SMOX in THYM (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	SMOX →	+1.140	+0.051	<.001	<.001	3	26
UVM	AMD1 →	+1.163	+0.045	<.001	<.001	3	24
LAML	LINC01433 →	+0.512	+0.045	.002	<.001	2	24
GBM	SLC16A10 →	+0.738	+0.046	<.001	<.001	3	20
SARC	SRSF12 →	+0.849	+0.039	<.001	<.001	3	19
UVM	TRAF3IP2-AS1 →	+0.602	+0.028	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006596 vs SMOX — THYM

Explore this scatter interactively →