Polyamine biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Polyamine biosynthetic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 14 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Polyamine biosynthetic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and LAML, show the opposite pattern, with higher activity associated with better survival.

LGG, UCS, and LUAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.710	0.877	<.001	51	view →
UCS	DFS	Median	II,III,IV	0.632	0.263	.001	44	view →
LUAD	DFS	Quartile	IV	0.424	0.896	.004	24	view →
ESCA	OS	Median	All	0.440	1.000	.008	23	view →
LAML	DFS	Tertile	All	0.716	0.382	.007	22	view →
MESO	DFS	Median	IV	0.164	0.488	.001	21	view →
COAD	DFS	Median	All	0.365	0.665	.002	16	view →
SCLC	OS	Tertile	II,III,IV	0.609	0.206	.006	15	view →
TGCT	DFS	Tertile	All	0.587	0.838	.009	14	view →
SARC	OS	Tertile	All	0.387	0.754	<.001	14	view →
LIHC	DFS	Tertile	All	0.460	0.589	.012	14	view →
THCA	DFS	Tertile	All	0.907	0.758	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0006596–LGG (OS)

Open the LGG breakdown →