Polyamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Polyamine biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMB1, NID1, and PSMB10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine biosynthetic process activity versus LAMB1 in HNSC (Pearson r = 0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LAMB1 →	+0.462	+0.064	<.001	.004	3	6
HNSC	NID1 →	+0.600	+0.072	<.001	<.001	3	6
LSCC	PSMB10 →	-0.415	-0.038	<.001	<.001	3	6
LSCC	CAST →	-0.278	-0.046	<.001	<.001	3	5
COAD	CLINT1 →	-0.237	-0.039	<.001	<.001	3	5
COAD	GCC2 →	-0.253	-0.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006596 vs LAMB1 — HNSC

Explore this scatter interactively →