Polyamine biosynthetic process

Across TCGA patient cohorts, RNA activity of the Polyamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HDAC1P1, TGM1, and LOX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine biosynthetic process activity versus HDAC1P1 in PDAC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HDAC1P1 →	+0.345	+0.143	.005	<.001	3	4
PDAC	TGM1 →	-0.328	-0.157	.006	<.001	3	4
UCEC	LOX →	-1.198	-0.414	<.001	.001	3	3
UCEC	EFCC1 →	+0.744	+0.382	<.001	.002	3	3
UCEC	PLCE1 →	+0.814	+0.192	.005	<.001	3	3
UCEC	NABP1 →	-0.557	-0.273	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006596 vs HDAC1P1 — PDAC

Explore this scatter interactively →