Polyamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Polyamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF3, ACY1, and MMP7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF3 grouped by Polyamine biosynthetic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RAPGEF3 →	+2.556	+1.554	<.001	<.001	2	5
CNS	ACY1 →	+0.784	+0.967	<.001	.001	3	4
PANCREAS	MMP7 →	+4.218	+0.869	.002	.005	3	3
CNS	ENOSF1 →	+1.546	+0.951	.005	.005	3	3
BREAST	IRF5 →	+1.155	+0.521	<.001	.002	3	3
OVARY	SLC28A1 →	+0.141	+0.601	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF3 by Polyamine biosynthetic process activity — URINARY_TRACT

Explore this box plot interactively →