Polyamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Polyamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AMD1, EIF1AX, and USP45, each associated with the pathway in up to 18 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine biosynthetic process activity versus AMD1 in BREAST (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AMD1 →	+1.038	+0.174	<.001	<.001	3	18
CNS	EIF1AX →	+0.400	+0.057	.005	.006	3	9
SKIN	USP45 →	+0.621	+0.120	.001	<.001	3	8
OVARY	LTV1 →	+0.777	+0.093	.002	.007	3	8
OVARY	WTAP →	+0.876	+0.124	<.001	<.001	3	8
BLOOD_Lymphoma	NUS1 →	+0.763	+0.097	.006	.008	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006596 vs AMD1 — BREAST

Explore this scatter interactively →