Polyamine biosynthetic process

Across TCGA cell cohorts, RNA activity of the Polyamine biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXA2, RND3, and AHNAK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyamine biosynthetic process activity versus FOXA2 in STOMACH (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FOXA2 →	+2.975	+0.512	.001	<.001	3	4
LARGE_INTESTINE	RND3 →	-0.910	-0.427	.001	.009	3	3
LARGE_INTESTINE	AHNAK2 →	-1.851	-0.424	.001	.009	3	3
STOMACH	AGMAT →	+3.256	+0.600	.001	<.001	3	3
STOMACH	ERICH2 →	-0.592	-0.468	.007	.003	3	3
BREAST	NUP155 →	+0.986	+0.515	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006596 vs FOXA2 — STOMACH

Explore this scatter interactively →