Ornithine metabolic process

Across TCGA patient cohorts, RNA activity of the Ornithine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR2, TREM1, and FCGR3B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ornithine metabolic process activity versus CXCR2 in LSCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CXCR2 →	+1.585	+0.279	<.001	<.001	3	7
GBM	TREM1 →	+1.413	+0.334	<.001	<.001	3	7
LSCC	FCGR3B →	+1.559	+0.174	<.001	<.001	3	6
GBM	CXCL8 →	+1.890	+0.258	.003	<.001	3	6
HNSC	FPR2 →	+1.021	+0.289	<.001	.001	3	6
LSCC	ADGRG3 →	+0.976	+0.242	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006591 vs CXCR2 — LSCC

Explore this scatter interactively →