Ornithine metabolic process

Across TCGA patient cohorts, RNA activity of the Ornithine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AZU1, BPI, and MMP8, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ornithine metabolic process activity versus AZU1 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AZU1 →	+0.890	+0.300	.001	.009	3	7
LSCC	BPI →	+1.368	+0.271	<.001	<.001	3	7
LSCC	MMP8 →	+1.315	+0.260	<.001	<.001	3	7
LSCC	PADI4 →	+1.294	+0.270	<.001	<.001	3	7
OV	DAXX_S495 →	-0.597	-0.118	<.001	<.001	3	6
UCEC	S100A12 →	+1.704	+0.500	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006591 vs AZU1 — BRCA

Explore this scatter interactively →