Biogenic amine metabolic process

Across TCGA patient cohorts, RNA activity of the Biogenic amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RX1, CSE1L, and PAICS, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biogenic amine metabolic process activity versus P2RX1 in LSCC (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	P2RX1 →	+0.697	+0.198	<.001	<.001	3	7
GBM	CSE1L →	-0.529	-0.196	<.001	<.001	3	6
LSCC	PAICS →	-0.645	-0.176	.001	<.001	3	6
LUAD	SKP2 →	-0.603	-0.171	<.001	<.001	3	6
LSCC	RFC4 →	-0.805	-0.142	<.001	.002	3	6
LSCC	PRKDC →	-0.646	-0.216	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006576 vs P2RX1 — LSCC

Explore this scatter interactively →