Biogenic amine metabolic process

Across TCGA cell cohorts, RNA activity of the Biogenic amine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BC9, SPATA2, and C16orf70, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biogenic amine metabolic process activity versus H2BC9 in LARGE_INTESTINE (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	H2BC9 →	-1.013	-0.238	.006	.007	3	5
BLOOD_Lymphoma	SPATA2 →	+0.549	+0.265	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	C16orf70 →	+0.935	+0.303	.003	.002	3	4
LARGE_INTESTINE	MRPS16 →	+0.533	+0.221	<.001	<.001	3	4
BREAST	CD37 →	-0.877	-0.267	.009	.002	3	4
BLOOD_Lymphoma	CHD1 →	+0.707	+0.239	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006576 vs H2BC9 — LARGE_INTESTINE

Explore this scatter interactively →